Upstream Bio Inc. Common Stock (UPB)
Stock · NASDAQ · Health Care
$2.75as of 10/16/2026
Price chart
Active signals
UPB Signal Track Record
How signals performed across all stocks →What UPB's price did in the 20 trading sessions after each past signal, compared with any 20-session window over the same period.
| Signal | Times | Median 20-session return | Higher after 20 sessions | Last signal |
|---|---|---|---|---|
| Volume Spike | 11 | +10.9% | 64% | October 8, 2026 |
| Bollinger Band Breakout | 8 | -1.1% | 50% | July 7, 2026 |
| Bollinger Band Breakdown | 4 | -23.8% | 25% | October 6, 2026 |
| Any 20-session window (baseline) | +0.8% | 51% |
Computed by MarketWall from daily closing prices since July 31, 2025. Returns are close-to-close and don't include dividends. Past results describe what happened before; they are not a forecast and not investment advice.
About UPB
Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was inco…
- Sector
- Health Care
- Industry
- Biotechnology: Pharmaceutical Preparations
- Employees
- 75
- Website
- upstreambio.com/
Fundamentals
- 1-day range
- $2.74$3.39
- Market cap
- $373.87M
- P/E (trailing)
- —
- P/E (forward)
- -0.99
- EPS (trailing)
- $-2.89
- Dividend yield
- —
- Beta
- 2.49
- Avg. volume
- 716.5K
How Upstream Bio Inc. Common Stock Makes Money
Where the revenue actually goes — FY2025 annual results
Source: 10-K filed Mar 26, 2026 · via SEC EDGAR / Finnhub
Forecasts
7 analyst ratings
Upstream Bio Inc. Common Stock Competitors
Chosen by industry and closest market cap.
- UPBUpstream Bio Inc. Common Stock$2.76▼ 18.10%Market cap $373.87MP/E —$3.29$33.68
- PRLDPrelude Therapeutics Incorporated Common Stock$3.26▼ 1.81%Market cap $372.74MP/E —$1.16$6.83
- DMACDiaMedica Therapeutics Inc. Common Stock$7.57▼ 5.85%Market cap $364.79MP/E —$5.25$10.42
- RCKTRocket Pharmaceuticals Inc. Common Stock$2.18▼ 7.63%Market cap $386.55MP/E —$2.42$5.45
- ENTAEnanta Pharmaceuticals Inc. Common Stock$11.1▼ 3.23%Market cap $387.91MP/E —$10.2$17.15
- NATRNature's Sunshine Products Inc. Common Stock$12.64▲ 0.00%Market cap $357.68MP/E 12.66$12.8$28.14
- ZNTLZentalis Pharmaceuticals Inc. Common Stock$2.13▼ 4.91%Market cap $355.93MP/E —$1.21$6.95
| Symbol | Market cap | P/E ratio | Price | 1D | 52-week range |
|---|---|---|---|---|---|
| UPB Upstream Bio Inc. Common Stock | $373.87M | — | $2.76 | ▼ 18.10% | $3.29$33.68 |
| PRLD Prelude Therapeutics Incorporated Common Stock | $372.74M | — | $3.26 | ▼ 1.81% | $1.16$6.83 |
| DMAC DiaMedica Therapeutics Inc. Common Stock | $364.79M | — | $7.57 | ▼ 5.85% | $5.25$10.42 |
| RCKT Rocket Pharmaceuticals Inc. Common Stock | $386.55M | — | $2.18 | ▼ 7.63% | $2.42$5.45 |
| ENTA Enanta Pharmaceuticals Inc. Common Stock | $387.91M | — | $11.1 | ▼ 3.23% | $10.2$17.15 |
| NATR Nature's Sunshine Products Inc. Common Stock | $357.68M | 12.66 | $12.64 | ▲ 0.00% | $12.8$28.14 |
| ZNTL Zentalis Pharmaceuticals Inc. Common Stock | $355.93M | — | $2.13 | ▼ 4.91% | $1.21$6.95 |
P/E shows — for peers not currently carrying a live signal of their own.
Insider Activity
Insider Actions →- Deykin Aaron · September 16, 2026 · Sale895 @ $5.49
- Houghton Adam · September 16, 2026 · Sale700 @ $5.49
- Ambrose Allison · September 16, 2026 · Sale485 @ $5.49
- Sutherland Everett Rand · September 16, 2026 · Sale2.1K @ $5.49
- GRAY MICHAEL · September 16, 2026 · Sale853 @ $5.49
- GRAY MICHAEL · June 16, 2026 · Sale853 @ $6.1
- Beckman Daniella · June 9, 2026 · Grant17.1K
- Ronald C. Renaud Jr. · June 9, 2026 · Grant17.1K
- Marcella K. Ruddy · June 9, 2026 · Grant17.1K
- Fleming Harold Edward · June 9, 2026 · Grant17.1K
- Chimovits Erez · June 9, 2026 · Grant17.1K
- Ratcliffe Liam · June 9, 2026 · Grant17.1K
Institutional Ownership
March 31, 2026
- Total shares held
- 43.51M
- Total value held
- $391.54M
- Institutional holders
- 136
- Unknown8.10M
- Unknown5.69M
- Unknown3.37M
- Unknown2.72M
- Unknown2.46M
- Unknown1.87M
- Unknown1.00M
- Unknown979.8K
- Unknown950.6K
- Unknown937.3K
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