SEPN

Septerna Inc. Common Stock (SEPN)

Stock · NASDAQ · Health Care

$36.35as of 10/16/2026

AI Market Commentary

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Synthesized from recent news and fundamentals/technical data -- not human analyst commentary or trader sentiment.

September 7, 2026

Septerna Schedules Upcoming Investor Conference Appearances. Septerna announced plans to participate in upcoming investor conferences. Such events are routine for publicly traded companies and provide opportunities for management to engage with institutional investors and analysts. The conferences may include presentations and one-on-one meetings, though no specific details about agenda topics were disclosed.

Active signals

Support level
$23.71
Industry
Biotechnology: Pharmaceutical Preparations

What SEPN's price did in the 20 trading sessions after each past signal, compared with any 20-session window over the same period.

SignalTimesMedian 20-session returnHigher after 20 sessions
Volume Spike10-0.1%50%
Bollinger Band Breakout8+8.1%63%
Bollinger Band Breakdown4+29.3%75%
Any 20-session window (baseline)+5.1%63%

Computed by MarketWall from daily closing prices since August 14, 2025. Returns are close-to-close and don't include dividends. Past results describe what happened before; they are not a forecast and not investment advice.

About SEPN

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric m…

Sector
Health Care
Industry
Biotechnology: Pharmaceutical Preparations
Employees
123

Fundamentals

1-day range
$34.66$37.09
Market cap
$1.78B
P/E (trailing)
—
P/E (forward)
-19.01
EPS (trailing)
$-0.54
Dividend yield
—
Beta
0.70
Avg. volume
390.5K
52-week range
$17.55$51.1
Next earnings: November 9, 2026 · EPS estimate $-0.55

How Septerna Inc. Common Stock Makes Money

Where the revenue actually goes — FY2025 annual results

market-wall.comTotalRevenue$45.95MR&D$97.58M (212%)SG&A$29.16M (63%)Tax$12.0K (0%)SEPN

Source: 10-K filed Mar 9, 2026 · via SEC EDGAR / Finnhub

Operating Income-$68.30M(-149%)

Forecasts

9 analyst ratings

Buy 94%
Hold 6%
Sell 0%
1-year price forecast
High
$62
+70.6%
Median
$51
+40.3%
Low
$48
+32.0%

Septerna Inc. Common Stock Competitors

Chosen by industry and closest market cap.

  • SEPN
    Septerna Inc. Common Stock
    $36.35
    ▼ 2.94%
    Market cap $1.78BP/E —
    $17.55$51.1
  • GENB
    Generate Biomedicines Inc. Common Stock
    $12.09
    ▼ 7.43%
    Market cap $1.78BP/E —
    $11$22.67
  • KARD
    Kardigan Inc. Common Stock
    $13.03
    ▼ 6.12%
    Market cap $1.79BP/E —
    $12.23$27
  • SRPT
    Sarepta Therapeutics Inc. Common Stock (DE)
    $17.1
    ▼ 3.88%
    Market cap $1.77BP/E —
    $14.68$24.68
  • SNDX
    Syndax Pharmaceuticals Inc. Common Stock
    $12.9
    ▼ 5.49%
    Market cap $1.76BP/E —
    $12.99$25.59
  • BCAX
    Bicara Therapeutics Inc. Common Stock
    $16.78
    ▼ 4.77%
    Market cap $1.81BP/E —
    $13.7$30.99
  • PRGO
    Perrigo Company plc Ordinary Shares
    $16.63
    ▲ 0.91%
    Market cap $1.74BP/E —
    $9.23$22.02

P/E shows — for peers not currently carrying a live signal of their own.

Institutional Ownership

March 31, 2026

Total shares held
45.33M
Total value held
$1.09B
Institutional holders
119
Top holders this quarter
  • Unknown7.00M
  • Unknown6.22M
  • Unknown4.40M
  • Unknown4.21M
  • Unknown3.15M
  • Unknown2.91M
  • Unknown2.00M
  • Unknown1.82M
  • Unknown1.35M
  • Unknown1.34M

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