BRVE
SCTX
SION
ELVN
QTTB

ORBIMED ADVISORS LLC

Known title: DirectorCIK: 0001055951

ORBIMED ADVISORS LLC's purchase track record

How the stock did after each of ORBIMED ADVISORS LLC's open-market purchases, measured from the purchase date. Several fills within a week count as one purchase.

Purchases measured
26
of 30 since November 4, 2021
Stock higher 6 months later
38%
3 months: 32%
Median 6-month return
-20.5%
3 months: -14.8%
Beat the S&P 500
35%
median -24.9% vs. index
PurchaseStockAmount3 months6 months
8/7/2026BRVE$34.92Mpendingpending
7/27/2026SCTX$15.00Mpendingpending
5/28/2026QTTB$15.00M+56.6%pending
4/21/2026PRLD$12.50M-12.6%pending
4/16/2026TRAW$998K-45.5%-66.9%
10/8/2025ACET$5.00M-43.1%-55.9%
8/25/2025STTK$5.47M+107.2%+325.6%
4/3/2025EWTX$10.00M-4.0%+10.5%
2/14/2025MBX$2.02M+7.2%+41.3%
2/10/2025SION$9.90M-42.0%-9.9%
10/15/2024UPB$14.03M-51.3%-66.2%
9/16/2024MBX$12.00M-11.6%-59.1%
6/17/2024IRON$3.00M+6.3%+47.5%
1/30/2024AVBP$8.00M-24.9%0.0%
1/25/2024ACET$7.50M-26.7%-38.9%
1/23/2024EWTX$5.00M+1.2%+40.9%
8/29/2023SPRY$3.10M-32.1%+24.4%
6/27/2023PASG$1.00M-18.6%+15.4%
6/27/2023ACET$1.83M-32.9%-22.1%
5/22/2023PRLD$5.00M-38.9%-37.1%
2/15/2023IRON$2.50M+43.1%+122.6%
11/8/2022CMPX$1.29M-7.1%-20.0%

Computed by MarketWall from SEC Form 4 filings and daily closing prices (close on the purchase date to the close about 3 and 6 months later). Companies that have since delisted are not included. Past results, not investment advice.

Associated companies

this person other insiders at BRVE

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September 26, 2026

Cathie Wood's ARKG adds Scribe Therapeutics to its biotech holdings. ARK Genomic Revolution ETF (ARKG) increased its position in Scribe Therapeutics, as reported by Yahoo and Benzinga. The addition places Scribe among four biotech names that the fund has recently loaded up on. The stock also appeared in a list of health‑care shares moving in the pre‑market session. This news brings additional attention to the company while the stock shows modest momentum on the chart.

this person other insiders at SCTX

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October 16, 2026

Sionna Shares Fall 37.6% Over 4 Weeks, Trend Reversal Possible. Sionna Therapeutics shares fell 37.6% over the past four weeks. The drop has pushed the stock into a low RSI zone of 23.4, suggesting it may be oversold. The price is near a key support level at $5.71, which has been tested 20 times. Analysts see a potential trend reversal, but the stock remains far below its 52‑week high of $54.97.

this person other insiders at SION

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October 11, 2026

Enliven's ENABLE-2 Trial Design Sparks New Questions. Enliven Therapeutics has clarified the design of its ENABLE-2 Phase 3 trial for relcobatinib in chronic myeloid leukemia, following questions raised by the trial’s structure. The company also confirmed FDA alignment on the study, while a separate patent dispute involving Halozyme and Merck has kept the leukemia treatment landscape in focus. These developments highlight the regulatory and strategic challenges Enliven faces as it moves toward clinical milestones.

this person other insiders at ELVN

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September 25, 2026

Q32 Bio to Present Late‑Breaking Results of Bempikibart Trial at EADV Congress. Q32 Bio will present late‑breaking results from Part B of its SIGNAL‑AA Phase 2a study of Bempikibart for alopecia areata at the European Academy of Dermatology and Venereology Congress. The company also shared additional 36‑week data from the same study earlier in the congress. These updates provide new information on the drug’s safety and efficacy profile, which may influence market perception of the company’s pipeline.

this person other insiders at QTTB

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October 13, 2026

PRLD announces collaboration and supply deal with Eli Lilly. Prelude Therapeutics disclosed a collaboration and supply agreement with Eli Lilly. The arrangement will have Prelude provide its CDK4/6 inhibitor abemaciclib and oral estrogen receptor antagonist imlunestrant for Lilly‑led clinical trials. Partnering with a large pharmaceutical company may expand Prelude's development pipeline and potential revenue sources. The stock is currently near its long‑term support level.

this person other insiders at PRLD

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October 2, 2026

Traws Pharma listed in Benzinga health care movers. Traws Pharma was included in Benzinga's recent lists of health care stocks moving in pre-market and after-market sessions. These mentions indicate that the stock experienced price volatility relative to its peers during those trading periods. The company's shares currently trade near the middle of their 52-week range, with an average analyst target of $1.00.

this person other insiders at TRAW

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September 29, 2026

Adicet Bio shares positive Phase 1 lupus data, Wedbush lifts target. Adicet Bio announced that its Phase 1 study of Prula‑cel in lupus patients showed positive safety and efficacy signals, and the company is moving forward with plans for a pivotal trial. Wedbush analysts kept an Outperform rating and raised their price target to $28, reflecting confidence in the data. The news comes as the stock trades near its 52‑week high, with analyst consensus targets averaging $34.83.

this person other insiders at ACET

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September 28, 2026

Keros Therapeutics Doses First Patient in Phase 2 Rinvatercept Trial. Keros Therapeutics has announced the dosing of the first patient in a Phase 2 clinical trial evaluating rinvatercept for Duchenne Muscular Dystrophy. This milestone marks a significant step in the development of the company's lead candidate. The stock is currently trading near its support level, with analysts setting an average price target of $19.83.

this person other insiders at KROS

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October 6, 2026

PMV Pharmaceuticals Adds Matt Eckler to Board. PMV Pharmaceuticals has appointed Matt Eckler, Ph.D., to its Board of Directors. This corporate update adds to the company's leadership team. The stock is currently trading near the top of its 52-week range, with an RSI of 69.0 indicating strong recent momentum.

this person other insiders at PMVP

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October 16, 2026

UBS initiates coverage on Shattuck Labs with $17 price target. UBS has started covering Shattuck Labs, assigning a price target of $17. This new analyst view comes as the company prepares to present research at UEG Week 2026. The stock is currently trading near its 52-week low, making this fresh institutional attention a notable development for the company.

this person other insiders at STTK

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October 3, 2026

ImageneBio Reports Inducement Grants Under Nasdaq Rule. ImageneBio has disclosed new inducement grants in compliance with Nasdaq Listing Rule 5635(c)(4). This filing is a standard corporate disclosure regarding compensation and does not report new clinical data or financial results. The stock is currently trading within its 52-week range, with an average analyst target of $18.00.

this person other insiders at IMA

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October 15, 2026

Corvus Pharma Q2 2026 Earnings Call Transcript Released. Corvus Pharmaceuticals released the transcript of its Q2 2026 earnings call. The document offers details on the company’s recent financial results and guidance for the upcoming period. Investors can review the call to better understand the company’s performance and strategic priorities.

this person other insiders at CRVS
this person other insiders at PASG

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September 25, 2026

Keybanc Initiates Coverage on NeuroPace (NPCE) with Overweight Rating. Keybanc has started coverage of NeuroPace, giving it an overweight rating and a price target of $18. This follows the recent average analyst target of $20, which sits near the top of the 52‑week range of $9.22 to $19.60. The new rating adds to the company's positive outlook as it trades near its support level of $14.01 with an RSI of 41.9.

this person other insiders at NPCE
this person other insiders at XTNT

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September 26, 2026

Compass Therapeutics faces analyst downgrades after FDA setback. Compass Therapeutics is facing renewed scrutiny following an FDA setback for tovecimig, which H.C. Wainwright described as a risky filing strategy. Several firms, including Citizens, Guggenheim, and Craig-Hallum, lowered their price targets to $4 or $8 while maintaining positive ratings. The stock's RSI is near 20.7, indicating it is currently trading in oversold territory.

this person other insiders at CMPX

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October 10, 2026

Edgewise Therapeutics Doses First Patient in Phase 2 Trial. Edgewise Therapeutics has dosed the first participant in its Phase 2 EQUINOX-HFpEF trial for EDG-15400, a drug intended to treat heart failure with preserved ejection fraction. This marks a key clinical milestone for the company. The stock is currently trading near its 52-week high, with analysts maintaining an average price target of $52.62.

this person other insiders at EWTX

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October 13, 2026

Disc Medicine faces valuation scrutiny and whale activity. Recent commentary questions whether Disc Medicine's stock price fully reflects its market position relative to competitors. Additionally, the stock appeared on a list of healthcare names showing significant large-scale trading activity. The stock is currently trading near its 52-week low, which provides context for these recent market observations.

this person other insiders at IRON

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October 16, 2026

MBX Biosciences to Attend Investor Conferences, Analyst Target Raised. MBX Biosciences will join several investor conferences in November, offering a chance for investors to hear about its pipeline. Stifel has kept a positive stance and lifted its target price to $84. Analysts are debating whether the recent 257% jump has pushed the stock above fair value, while others question if the pullback from a strong year run still leaves room for upside.

this person other insiders at MBX
this person other insiders at UPB

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September 30, 2026

Aquestive news highlights biotech valuation dynamics. Recent market discussion focused on Aquestive Therapeutics and the pricing of anaphylaxis drug success. While this news does not directly involve ARS Pharmaceuticals, it reflects broader sector sentiment regarding biotech valuations. ARS Pharmaceuticals is currently trading with an RSI of 37.5, indicating mild oversold conditions relative to its recent range.

this person other insiders at SPRY

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September 30, 2026

Craig-Hallum initiates coverage on TELA Bio with $2 target. Craig-Hallum has started tracking TELA Bio, assigning a price target of $2. This new analyst note aligns with the current average analyst target of $2.08. The stock is currently trading above its 52-week low of $0.50, with recent technical indicators showing momentum near the upper end of its recent range.

this person other insiders at TELA

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September 25, 2026

AVBP Included in Whale Activity Among 10 Health Care Stocks. AVBP was listed among ten health‑care stocks that saw significant whale activity during today's trading session. The move indicates that large institutional investors are actively buying shares of the company. This activity could signal increased confidence in AVBP's prospects. The stock remains within its 52‑week range and near the midpoint of analyst target levels.

this person other insiders at AVBP

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October 13, 2026

DMRA Shares Rise Amid Valuation Debate. Damora Therapeutics shares have climbed recently, drawing attention to potential overvaluation relative to book value. While the stock is trading near its 52-week low, analyst targets remain significantly higher than the current price. This divergence highlights a split between short-term technical weakness and long-term fundamental expectations.

this person other insiders at DMRA

Transaction History

BRVE▼ Sell—
BRVE▲ Buy$30.0M
BRVE▲ Buy$4.9M
SCTX▲ Buy$15.0M
SCTX▼ Sell—
SION▼ Sell$3.9M
SION▼ Sell$5.3M
ELVN▼ Sell$1.1M
ELVN▼ Sell$66K
ELVN▼ Sell$35.7M
ELVN▼ Sell$2.1M
ELVN▼ Sell$409K
ELVN▼ Sell$12.3M
QTTB▲ Buy$10.0M
QTTB▲ Buy$5.0M
SION▼ Sell$4K
SION▼ Sell$8.5M
SION▼ Sell$2.7M
SION▼ Sell$2.2M
PRLD▲ Buy$7.5M
PRLD▲ Buy$5.0M
SION▼ Sell$131K
SION▼ Sell$2.3M
SION▼ Sell$10.3M
TRAW▲ Buy$998K
SION▼ Sell$10.5M
SION▼ Sell$2.1M
ACET▼ Sell$264K
ACET▼ Sell$205K
ACET▼ Sell$191K
ACET▼ Sell$15K
SION▼ Sell$1.3M
SION▼ Sell$84K
SION▼ Sell$1.5M
SION▼ Sell$39K
SION▼ Sell$4K
SION▼ Sell$40K
SION▼ Sell$71K
SION▼ Sell$530K
SION▼ Sell$4.2M
KROS▼ Sell$2.5M
KROS▼ Sell$1.3M
PMVP▼ Sell$1.5M
ACET▲ Buy$1.5M
ACET▲ Buy$3.5M
PMVP▼ Sell$900K
STTK▲ Buy$4.6M
STTK▲ Buy$912K
IMA▲ Buy$208K
CRVS▼ Sell$4.9M
CRVS▼ Sell$4.9M
PASG▼ Sell$70K
PASG▼ Sell$46K
PASG▼ Sell$81K
NPCE▼ Sell$2.1M
NPCE▼ Sell$542K
PASG▼ Sell$22K
PASG▼ Sell$30K
PASG▼ Sell$27K
PASG▼ Sell$25K
PASG▼ Sell$20K
PASG▼ Sell$4K
XTNT▼ Sell$23.5M
XTNT▼ Sell$7.2M
CMPX▼ Sell$5.7M
EWTX▲ Buy$7.5M
EWTX▲ Buy$2.5M
IRON▼ Sell$164K
IRON▼ Sell$106K
IRON▼ Sell$41K
IRON▼ Sell$71K
IRON▼ Sell$184K
IRON▼ Sell$285K
IRON▼ Sell$51K
IRON▼ Sell$79K
IRON▼ Sell$20K
IRON▼ Sell$730K
IRON▼ Sell$1.1M
IRON▼ Sell$282K
IRON▼ Sell$33K
IRON▼ Sell$51K
IRON▼ Sell$13K
IRON▼ Sell$1.5M
IRON▼ Sell$2.3M
IRON▼ Sell$584K
IRON▼ Sell$498K
IRON▼ Sell$771K
IRON▼ Sell$193K
IRON▼ Sell$3.7M
IRON▼ Sell$5.8M
IRON▼ Sell$1.4M
IRON▼ Sell$7K
IRON▼ Sell$12K
IRON▼ Sell$3K
MBX▲ Buy$532K
MBX▲ Buy$1.0M
MBX▲ Buy$178K
MBX▲ Buy$291K
SION▼ Sell—
SION▲ Buy$9.9M
PASG▼ Sell$47K
PASG▼ Sell$12K
PASG▼ Sell$83K
PASG▼ Sell$51K
PASG▼ Sell$37K
PASG▼ Sell$15K
PASG▼ Sell$138K
PASG▼ Sell$64
PASG▼ Sell$6K
PASG▼ Sell$46K
PASG▼ Sell$17K
PASG▼ Sell$60K
UPB▼ Sell—
UPB▲ Buy$2.8M
UPB▼ Sell—
UPB▲ Buy$11.2M
PASG▼ Sell$28K
PASG▼ Sell$19K
PASG▼ Sell$81K
MBX▲ Buy$8.0M
PASG▼ Sell$47K
MBX▲ Buy$4.0M
MBX▼ Sell—
MBX▼ Sell—
SPRY▼ Sell$1.1M
SPRY▼ Sell$906K
SPRY▼ Sell$5.1M
SPRY▼ Sell$5.3M
SPRY▼ Sell$194K
KROS▼ Sell$9.7M
KROS▼ Sell$1.3M
TELA▼ Sell$166K
TELA▼ Sell$64K
TELA▼ Sell$1.8M
IRON▲ Buy$1.0M
IRON▲ Buy$1.6M
IRON▲ Buy$395K
ELVN▼ Sell$737K
ELVN▼ Sell$22.1M
NPCE▼ Sell$66K
NPCE▼ Sell$124K
NPCE▼ Sell$220K
NPCE▼ Sell$25K
NPCE▼ Sell$311K
NPCE▼ Sell$346K
NPCE▼ Sell$256K
NPCE▼ Sell$37K
NPCE▼ Sell$4K
NPCE▼ Sell$197K
NPCE▼ Sell$333K
NPCE▼ Sell$6.7M
AVBP▼ Sell—
AVBP▼ Sell—
AVBP▼ Sell—
AVBP▼ Sell—
AVBP▲ Buy$4.0M
AVBP▲ Buy$4.0M
ACET▲ Buy$4.4M
ACET▲ Buy$2.5M
ACET▲ Buy$581K
EWTX▲ Buy$5.0M
IRON▼ Sell$102K
IRON▲ Buy$66K
IRON▼ Sell$6K
IRON▼ Sell$6K
IRON▼ Sell$13.0M
IRON▼ Sell$8.4M
IRON▼ Sell$3.2M
IRON▼ Sell$3.3M
IRON▼ Sell$2.1M
IRON▼ Sell$826K
IRON▼ Sell$559K
IRON▼ Sell$217K
IRON▼ Sell$866K
PMVP▼ Sell$196K
NPCE▼ Sell$6K
NPCE▼ Sell$69K
SPRY▲ Buy$3.1M
DMRA▼ Sell$29K
DMRA▼ Sell$187K
DMRA▼ Sell$402K
IMA▲ Buy—
DMRA▼ Sell$80K
DMRA▼ Sell$89K
DMRA▼ Sell$459K
DMRA▼ Sell$23K
DMRA▼ Sell$14K
DMRA▼ Sell$78K
DMRA▼ Sell$24K
DMRA▼ Sell$127K
DMRA▼ Sell$317K
PASG▲ Buy$483K
ACET▲ Buy$261K
ACET▲ Buy$522K
ACET▲ Buy$924K
ACET▲ Buy$121K
PASG▲ Buy$519K
PRLD▲ Buy$5.0M
ELVN▲ Buy$9K
TELA▼ Sell$261K

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