INCY
KOD
ONC
CELC
MDGL

BAKER BROS. ADVISORS LP

Known title: DirectorCIK: 0001263508

BAKER BROS. ADVISORS LP's purchase track record

How the stock did after each of BAKER BROS. ADVISORS LP's open-market purchases, measured from the purchase date. Several fills within a week count as one purchase.

Purchases measured
34
of 35 since August 17, 2021
Stock higher 6 months later
50%
3 months: 68%
Median 6-month return
+2.9%
3 months: +15.6%
Beat the S&P 500
53%
median +6.4% vs. index
PurchaseStockAmount3 months6 months
9/28/2026KOD$156.99Mpendingpending
12/18/2025KOD$60.00M-14.1%+37.0%
12/11/2025KYMR$172.50M-11.7%-5.5%
11/20/2025TRDA$262K+24.4%-31.2%
11/10/2025TRDA$1.35M+45.3%-3.6%
9/8/2025CELC$9.57M+66.4%+81.4%
8/18/2025MDGL$61.92M+41.4%+24.5%
6/30/2025KYMR$28.84M+34.1%+84.1%
3/17/2025IMCR$23.99M+9.6%+14.6%
12/30/2024KALA$2.00M-16.6%-30.7%
12/13/2024BCYC$21.23M-29.8%-39.4%
8/20/2024KYMR$46-7.9%-20.2%
12/12/2023MDGL$30.07M+18.2%+31.4%
11/21/2023MDGL$12.13M+21.9%+28.7%
11/13/2023MDGL$35.56M+48.2%+44.7%
8/15/2023NGNE$1.46M+4.5%+123.2%
5/22/2023ACAD$22.71M+22.3%-7.6%
6/2/2022KOD$4.45M+34.9%-7.1%
6/2/2022TRDA$261K+114.5%+191.6%
5/25/2022KOD$2.36M+68.7%+10.6%
5/24/2022TRDA$137K+118.8%+139.7%

Computed by MarketWall from SEC Form 4 filings and daily closing prices (close on the purchase date to the close about 3 and 6 months later). Companies that have since delisted are not included. Past results, not investment advice.

Associated companies

AI Market Commentary

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October 17, 2026

Incyte receives mixed analyst updates with price target changes. Incyte saw two recent analyst actions with differing views. Truist Securities raised its price target to $115 while maintaining a Hold rating. Conversely, HC Wainwright reiterated a Buy rating and kept its target at $152. These moves reflect a wide range of expectations among analysts for the stock's future performance.

this person other insiders at INCY

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October 12, 2026

Kodiak Sciences (KOD) Analyst Raises Target, Presents Late‑Stage Data. HC Wainwright & Co. kept its positive stance on Kodiak Sciences and lifted its price target to $126. The company will share clinical results from three late‑stage programs at the American Academy of Ophthalmology conference. Recent reports note the stock is trading at a premium after trial news, while some analysts consider it potentially overvalued. It also appears on a list of health‑care stocks that could face difficulties in Q4.

this person other insiders at KOD

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October 17, 2026

BeOne Medicines Receives Rating Upgrade and Added to Top-Rated List. BeOne Medicines Ltd. has been upgraded to a top rating by analysts. It was also added to a list of top-rated stocks for the week. The upgrade follows recent earnings and infrastructure updates discussed in a broader market analysis. The move may influence investor perception of the company.

this person other insiders at ONC

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October 10, 2026

Celcuity Shares Fall 17% After REVTORPYK Launch and NDA Filing. Celcuity’s stock fell 17.3% after the company announced the launch of its REVTORPYK product in the U.S. and filed a new drug application. The company also said it will present at the European Society for Medical Oncology congress, adding to the mix of upcoming events. With the price near its 14‑day support level of $87.46 and an RSI of 30.1, the move reflects a short‑term reaction to the news rather than a long‑term trend.

this person other insiders at CELC

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October 6, 2026

Madrigal Publishes MAESTRO-NASH Secondary Analysis Data. Madrigal Pharmaceuticals has published data from a pre-specified secondary analysis of its Phase 3 MAESTRO-NASH study in the Journal of Hepatology. The analysis evaluates how patients with altered MASH profiles respond to Rezdiffra. This update provides additional clinical context for the drug's performance in specific patient groups.

this person other insiders at MDGL

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October 9, 2026

Denali Therapeutics Shares Test Fair Value Amid Pullback. Denali Therapeutics shares have pulled back, testing the $19.37 support level. The 14‑day RSI sits at 30, indicating a possible oversold condition, while the support_reject signal suggests the level may hold. Analysts average a target of $36.06, with a range of $27 to $42, well above the current price and the 52‑week low of $13.75. The pullback could be seen as a chance to assess fair value.

this person other insiders at DNLI

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October 10, 2026

RBC Lowers ACAD Target to $36 Amid Patent and Phase 2 Updates. RBC Capital maintained an Outperform rating on Acadia Pharmaceuticals but lowered its price target to $36. This move comes as the company reports progress on patents and Phase 2 trials. Recent articles also suggest the stock may be trading below its estimated fair value, highlighting a contrast between current market pricing and fundamental developments.

this person other insiders at ACAD

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October 8, 2026

Kiniksa Reports Strong Growth and Accelerating Earnings. Kiniksa Pharmaceuticals has reported earnings that are accelerating, supporting its growth narrative. Analysts note that the company’s performance shows little room for disappointment, reinforcing confidence in its business model. The company’s recent data underscores its position as a solid growth player in the pharmaceutical sector.

this person other insiders at BCYC

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October 16, 2026

Raymond James initiates coverage on Kymera with Outperform rating. Raymond James has started covering Kymera Therapeutics, assigning an Outperform rating and a price target of $140. This new analyst note adds to the current consensus, which has an average target of $139.35 from 23 analysts. Recent discussions also question whether the company's pipeline is over-hyped or developing into a major therapeutic success.

this person other insiders at KYMR

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September 27, 2026

TRDA sees institutional interest from NVIDIA and Merck. The Benzinga report notes that institutional investors linked to NVIDIA and Merck have increased their positions in TRDA. This activity signals growing confidence in the company’s pipeline and may attract additional attention from other investors. The move comes as TRDA trades near the lower end of its 52‑week range, providing a potential entry point for those monitoring the stock.

this person other insiders at TRDA

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October 1, 2026

KALA Bio Signs LOI to Acquire Telehealth Platform. KALA Bio shares surged 57% after hours following the announcement of a non-binding letter of intent to acquire a nationwide telehealth platform. The target company has generated approximately $48 million in sales since inception. Additionally, the company signed a separate agreement to resell genetic testing products through a U.S. DNA testing platform.

this person other insiders at KALA

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October 5, 2026

VTVT Completes Phase 3 Cadisegliatin Trial Enrollment. vTv Therapeutics announced that enrollment for its phase 3 cadisegliatin trial in type 1 diabetes has been completed. The milestone moves the program closer to the next study stage and may influence future clinical and commercial outlook. The stock is currently trading near a long‑standing support level that has been tested many times.

this person other insiders at VTVT

Transaction History

INCY▲ Buy$0
INCY▲ Buy$0
KOD▲ Buy$122K
KOD▲ Buy$102K
KOD▲ Buy$875K
KOD▲ Buy$1.7M
KOD▲ Buy$52K
KOD▲ Buy$7K
KOD▲ Buy$9.3M
KOD▲ Buy$7.4M
KOD▲ Buy$9.6M
KOD▲ Buy$556K
KOD▲ Buy$878K
KOD▲ Buy$256K
KOD▲ Buy$3K
KOD▲ Buy$1.1M
KOD▲ Buy$2.4M
KOD▲ Buy$339K
KOD▲ Buy$459K
KOD▲ Buy$53K
KOD▲ Buy$8K
KOD▲ Buy$97K
KOD▲ Buy$83K
KOD▲ Buy$42K
KOD▲ Buy$711K
KOD▲ Buy$3.3M
KOD▲ Buy$164K
KOD▲ Buy$5.5M
KOD▲ Buy$1.2M
KOD▲ Buy$22K
KOD▲ Buy$4.7M
KOD▲ Buy$3.7M
KOD▲ Buy$20.2M
KOD▲ Buy$1.4M
KOD▲ Buy$1.3M
KOD▲ Buy$343K
KOD▲ Buy$233K
KOD▲ Buy$223K
KOD▲ Buy$1.4M
KOD▲ Buy$85K
KOD▲ Buy$145K
KOD▲ Buy$5.7M
KOD▲ Buy$83K
KOD▲ Buy$140K
KOD▲ Buy$17.7M
KOD▲ Buy$27K
KOD▲ Buy$1.4M
KOD▲ Buy$10.4M
KOD▲ Buy$521K
KOD▲ Buy$200K
KOD▲ Buy$75K
KOD▲ Buy$52K
KOD▲ Buy$5K
KOD▲ Buy$1K
KOD▲ Buy$23K
KOD▲ Buy$2.8M
KOD▲ Buy$70K
KOD▲ Buy$15K
KOD▲ Buy$392K
KOD▲ Buy$31K
KOD▲ Buy$32K
KOD▲ Buy$517K
KOD▲ Buy$6.6M
KOD▲ Buy$544K
KOD▲ Buy$177K
KOD▲ Buy$161K
KOD▲ Buy$11K
KOD▲ Buy$2.7M
KOD▲ Buy$1.2M
KOD▲ Buy$83K
KOD▲ Buy$361K
KOD▲ Buy$2.3M
KOD▲ Buy$5.8M
KOD▲ Buy$8.7M
KOD▲ Buy$570K
KOD▲ Buy$3.9M
KOD▲ Buy$137K
KOD▲ Buy$16K
KOD▲ Buy$330K
KOD▲ Buy$620K
KOD▲ Buy$1.6M
KOD▲ Buy$281K
KOD▲ Buy$270K
KOD▲ Buy$442K
ONC▲ Buy$1.1M
ONC▲ Buy$1.1M
CELC▼ Sell$26.8M
CELC▼ Sell$291.0M
INCY▲ Buy$0
INCY▲ Buy$0
MDGL▲ Buy$0
MDGL▲ Buy$0
ONC▲ Buy$0
ONC▲ Buy$0
INCY▲ Buy$0
INCY▲ Buy$0
DNLI▲ Buy$0
DNLI▲ Buy$0
ACAD▲ Buy$0
KNSA▲ Buy$0
KNSA▲ Buy$0
ACAD▲ Buy$0
ONC▼ Sell$66K
ONC▼ Sell$65K
ONC▼ Sell$66K
ONC▼ Sell$65K
INCY▲ Buy$1.3M
INCY▲ Buy$1.3M
INCY▲ Buy$0
INCY▲ Buy$0
BCYC▲ Buy$0
BCYC▲ Buy$0
INCY▲ Buy$0
INCY▲ Buy$0
KOD▲ Buy$55.0M
KOD▲ Buy$5.0M
KYMR▲ Buy$158.1M
KYMR▲ Buy$14.4M
TRDA▲ Buy$121K
TRDA▲ Buy$11K
TRDA▲ Buy$119K
TRDA▲ Buy$11K
TRDA▲ Buy$57K
TRDA▲ Buy$91K
TRDA▲ Buy$8K
TRDA▲ Buy$625K
TRDA▲ Buy$233K
TRDA▲ Buy$21K
TRDA▲ Buy$8K
TRDA▲ Buy$86K
TRDA▲ Buy$183K
TRDA▲ Buy$17K
TRDA▲ Buy$2K
TRDA▲ Buy$21K
KALA▼ Sell$70K
KALA▼ Sell$641K
INCY▲ Buy$0
INCY▲ Buy$0
KALA▼ Sell$34K
KALA▼ Sell$312K
CELC▲ Buy$786K
CELC▲ Buy$8.5M
CELC▲ Buy$244K
CELC▲ Buy$23K
VTVT▲ Buy—
VTVT▲ Buy—
MDGL▲ Buy$183K
MDGL▲ Buy$2.0M
MDGL▲ Buy$3.7M
MDGL▲ Buy$158K
MDGL▲ Buy$5.2M
MDGL▲ Buy$977K
MDGL▲ Buy$90K
MDGL▲ Buy$142K
MDGL▲ Buy$13K
MDGL▲ Buy$1.7M
MDGL▲ Buy$481K
MDGL▲ Buy$1.6M
MDGL▲ Buy$143K
MDGL▲ Buy$1.1M
MDGL▲ Buy$100K
MDGL▲ Buy$434K
MDGL▲ Buy$40K
MDGL▲ Buy$3.6M
MDGL▲ Buy$333K
MDGL▲ Buy$338K
MDGL▲ Buy$731K
MDGL▲ Buy$67K
MDGL▲ Buy$163K
MDGL▲ Buy$2.0M
MDGL▲ Buy$188K
MDGL▲ Buy$1.0M
MDGL▲ Buy$93K
MDGL▲ Buy$523K
MDGL▲ Buy$48K
MDGL▲ Buy$1.8M
MDGL▲ Buy$77K
MDGL▲ Buy$1.0M
MDGL▲ Buy$93K
MDGL▲ Buy$187K
MDGL▲ Buy$2.0M
MDGL▲ Buy$181K
MDGL▲ Buy$3.1M
MDGL▲ Buy$282K
MDGL▲ Buy$885K
MDGL▲ Buy$2.0M
MDGL▲ Buy$82K
MDGL▲ Buy$3.0M
MDGL▲ Buy$274K
MDGL▲ Buy$838K
MDGL▲ Buy$325K
MDGL▲ Buy$30K
MDGL▲ Buy$681K
MDGL▲ Buy$63K
MDGL▲ Buy$2.7M
MDGL▲ Buy$253K
MDGL▲ Buy$10.0M
MDGL▲ Buy$3.8M
MDGL▲ Buy$917K
MDGL▲ Buy$347K

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